31 March 2022: Perry - D

AIDS, (without adaptations), is the next topic for Dr Perry to wrestle with. His starting point is similar as for non-A-non-B. He pretty much came to it like the average man or woman in the street, little actual facts but just hearing bits and pieces about it. Once in post, and he started to attend conferences, he picked up increasingly technical information, especially as AIDS became seen as a risk in blood product use. The immediate suggestions for AIDS virus inactivation included considerations of loss of yield (for example, 25% down due to the added processing).

Boulton, Ludlum and Perry agreed not to discuss publicly their ongoing trial activity. The justification was that they were not ready to go public.

AIDS also led to exploration of the various options for viral inactivation; pasteurisation, heat treatment, UV, ethanol  etc. Early attempts at putting numbers to cases and risk ratios was very crude, but there was so little to go on. The added focus on safety elicited a 1983 BPL admission through it's own research that NHS products were no better than commercial products, with respect to disease transmission. If this was acknowledged so early on, why was it allowed to be proselytised for so long, leading to the grossly overplayed and mostly inaccurate concept of US-bad, UK-good? What a massive red herring this has proved to be.

The effort to kill off the increasingly likely AIDS in blood hazard became a global race. The CDC (Centre for Disease Control) in the US was well placed to be at the forefront of developments (or knowledge of them) due to so many commercial producers having to be regulated in their home country of America.

The PIL (Product Information Leaflet) became even more important as a way of conveying information to, primarily, patients says Dr Perry. Coagulation factors were subject to requiring the insertion of PIL inserts alongside the vial of treatment. Dr Perry was a major contributor to the wording or reviewing of inserts into factor concentrates produced by PFC. During Pen***e, Dr Perry saw the need for using language suitable for the lay person, including warnings. But the leaflets were, according to Dr Perry, primarily aimed at doctors (and pharmacists, although factor concentrates were not supplied through pharmacies).

We'll be back tomorrow to this gripping subject of the text to go on leaflets. Oh goodie.

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